Chicken and Stuffing Casserole: Your Ultimate Guide to Comfort Food Made Easy

There’s something special about a dish that delivers warmth, simplicity, and satisfaction in a single bite. If your evenings are often a race against the clock, and you find yourself choosing convenience over comfort, this is the recipe that changes the game. Chicken and stuffing casserole isn’t just another weeknight meal—it’s a shortcut to home-cooked happiness. It brings together hearty, wholesome ingredients in one baking dish, offering a delicious way to feed your family without the stress.

This guide will walk you through everything you need to know to make the perfect chicken and stuffing casserole. Whether you’re new to casseroles or a seasoned home cook looking for a quicker version, you’ll find exactly what you need here—from the right ingredients and step-by-step instructions to clever tips, variations, and nutritional insights. Let’s get started.

Ingredients You’ll Need for Chicken and Stuffing Casserole

You won’t need a long shopping list or a full pantry to make this dish. That’s part of what makes it so appealing. With just a handful of everyday ingredients, you’ll be able to pull off a casserole that tastes like you spent hours in the kitchen.

Here’s what you need:

• 1 box chicken-flavored Stove Top Stuffing (or your favorite brand)
• 1–2 pounds boneless, skinless chicken breasts, cut into 1-inch cubes
• 1 can of cream of chicken soup (feel free to swap with cream of mushroom or celery)
• 1/3 cup sour cream (adds a creamy texture and tang)
• 16 ounces frozen mixed vegetables (no need to thaw)
• 4–5 garlic cloves, minced
• Salt and pepper, to taste

These ingredients are easy to keep on hand, and many are already in your pantry or freezer. That’s why this casserole has become a go-to for busy households and budget-conscious families.

Step-by-Step Instructions to Make It Right

This casserole is all about layering flavor and texture. You’ll start by prepping your ingredients, then layer them in a single dish, bake, and serve. Follow these steps, and you’ll have a dinner that feels like it came from your grandma’s kitchen—even if you only spent 10 minutes preparing it.

Step 1 – Preheat and Prep Your Dish

Start by preheating your oven to 400°F. Spray a 9×13-inch baking dish with cooking spray to ensure easy cleanup later.

Step 2 – Mix the Base

In a large mixing bowl, combine your cubed chicken, cream of chicken soup, sour cream, minced garlic, frozen vegetables, salt, and pepper. Stir until everything is evenly coated.

This mixture is your casserole base—it’s creamy, savory, and full of hearty protein and vegetables.

Step 3 – Layer the Base

Spread the chicken and vegetable mixture evenly across the bottom of your prepared baking dish. You want the layer to be even so everything cooks at the same rate.

Step 4 – Prepare the Stuffing

Cook the stuffing according to the instructions on the package. It typically only takes a few minutes. The key here is to let the stuffing soak up the hot water and seasonings so it fluffs up properly.

Once it’s ready, spoon the stuffing mixture over the chicken base. Use the back of your spoon to spread it evenly.

Step 5 – Bake

Place your casserole dish in the preheated oven. Bake for 30 minutes, or until the chicken is fully cooked and the top of the stuffing is lightly browned. If you’re using pre-cooked chicken, reduce the cooking time to 20 minutes to avoid drying it out.

Once done, remove from the oven and let it sit for 5 minutes. This gives the flavors time to settle and makes serving easier.

Expert Tips to Make It Even Better

Want to level up your casserole? These tips will help you get the most out of this already excellent dish.

• Add cheese: Sprinkle shredded cheddar or Colby Jack on top of the stuffing before baking for a gooey, golden finish.
• Go spicy: A pinch of crushed red pepper flakes or a dash of hot sauce can give your casserole a welcome kick.
• Use rotisserie chicken: This is a great way to cut down on prep time and use up leftovers.
• Skip defrosting: Frozen veggies can be used straight from the freezer. No need to thaw—just mix them in.
• Even cuts cook better: Try to dice the chicken into uniform 1-inch cubes so it cooks evenly.
• Make it ahead: Prep everything the night before and refrigerate. When you’re ready to bake, just add 10 minutes to the cooking time.

Recipe Variations You Can Try

The beauty of chicken and stuffing casserole is how easy it is to customize. Here are a few ideas to put your own spin on it.

• Turkey instead of chicken: Perfect for post-Thanksgiving leftovers.
• Different soups: Swap cream of chicken for mushroom or celery, depending on your flavor preference.
• Add more vegetables: Fresh spinach, broccoli florets, or diced zucchini are all great additions.
• Mix in bacon: Cooked, crumbled bacon adds smokiness and crunch.
• Use milk instead of sour cream: For a slightly lighter texture and a different flavor base.

How to Store, Reheat, and Freeze

One of the biggest advantages of casseroles is how well they keep. You can make it ahead, enjoy leftovers, or freeze portions for later.

Refrigerator storage: Keep any leftovers in an airtight container. They’ll stay fresh for 3–4 days.

Freezer storage: Wrap tightly with foil and freeze for up to 3 months. If freezing a full dish, let it thaw in the refrigerator overnight before baking.

Reheating: Reheat in the oven at 350°F until warmed through (about 15–20 minutes), or use the microwave if you’re in a hurry.

What to Serve Alongside Chicken and Stuffing Casserole

While this dish is technically a full meal, you might want to add a side or two to round out your dinner. Here are a few easy pairings:

• Salad: A fresh garden salad with vinaigrette balances the richness of the casserole.
• Bread: Dinner rolls, garlic bread, or even cornbread work wonderfully.
• Roasted vegetables: Try roasted asparagus, brussels sprouts, or carrots for added texture and nutrition.
• Fruit: A bowl of fresh-cut fruit or fruit salad can lighten up the meal and satisfy your sweet tooth.

Nutritional Information (Per Serving)

Understanding what goes into your meals is key, especially if you’re watching your intake. Here’s a breakdown of what you’re getting in one serving (based on 6 servings total):

• Calories: 185
• Carbohydrates: 17g
• Sugar: 0.3g
• Sodium: 318mg
• Fat: 4g
• Saturated Fat: 2g
• Unsaturated Fat: 2g
• Trans Fat: 0.01g
• Fiber: 3g
• Protein: 20g
• Cholesterol: 56mg

These values make chicken and stuffing casserole a well-balanced option that’s rich in protein and reasonably low in calories.

FAQ – Chicken and Stuffing Casserole

Conclusion

Chicken and stuffing casserole is more than just a quick dinner—it’s a solution to your busy schedule, a comfort on hectic evenings, and a reliable favorite that satisfies everyone at the table. It brings together humble ingredients and turns them into something greater than the sum of its parts. Whether you’re feeding a family, preparing a meal for someone in need, or just craving something hearty, this casserole delivers every time.

Now it’s your turn. Gather your ingredients, preheat your oven, and take a little time to create something warm and nourishing. And when you’ve had your first bite, don’t be surprised if you find yourself reaching for seconds—or making it again next week. This is one recipe that’s bound to become part of your permanent rotation.

More Tasty Ideas

• Leftover Turkey Casserole: A perfect complement to chicken and stuffing casserole, this recipe transforms post-holiday turkey into a comforting, creamy bake. It’s layered with vegetables, gravy, and stuffing—rich in flavor and incredibly satisfying.
• Cheesy Broccoli Casserole: This dish adds a cheesy twist to the classic casserole format, combining tender broccoli florets with a creamy cheese sauce and crispy topping. It’s a hearty side or meatless main that pairs well with roasted chicken or turkey.
• Garlic Brown Sugar Chicken Thighs: For a savory-sweet variation, this recipe delivers juicy chicken thighs baked in a garlic and brown sugar glaze. It shares that comforting, baked chicken element while adding bold flavors that work beautifully with a side of stuffing or mashed potatoes.

Chicken and Stuffing Casserole

Print Recipe

This chicken and stuffing casserole is a comforting, all-in-one dish combining tender chicken, mixed vegetables, creamy soup, and flavorful stuffing. It’s quick to prepare and perfect for busy weeknights or cozy family dinners.

• Author: Benchi
• Prep Time: 10 minutes
• Cook Time: 30 minutes
• Total Time: 40 minutes
• Yield: 6 servings
• Category: Main Course
• Method: Baking
• Cuisine: American
• Diet: Low Calorie

Ingredients

• 1 box Stove Top Stuffing (chicken flavored)
• 2 lbs boneless, skinless chicken breasts, diced into 1-inch pieces
• 1 can cream of chicken soup
• 1/3 cup sour cream
• 16 oz frozen mixed vegetables
• 4-5 garlic cloves, minced
• Salt, to taste
• Black pepper, to taste

Instructions

1. Preheat oven to 400°F and spray a 9×13-inch baking dish with non-stick cooking spray.
2. In a large bowl, combine diced chicken, cream of chicken soup, sour cream, garlic, vegetables, salt, and pepper.
3. Spread the chicken mixture evenly in the bottom of the prepared baking dish.
4. Prepare stuffing according to the package directions.
5. Spread the cooked stuffing evenly over the chicken mixture.
6. Bake uncovered for 30 minutes or until the chicken is cooked through and the top is lightly browned.
7. Let cool for 5 minutes before serving.

Notes

• You can substitute cream of mushroom or cream of celery soup.
• Add shredded cheese on top before baking for extra flavor.
• Use leftover cooked chicken or rotisserie chicken to reduce cook time.
• No need to thaw frozen vegetables before adding.
• To make ahead, assemble the dish and refrigerate; add 10 minutes to baking time when ready to cook.